Abstract
The effect of some sugars in different concentrations and some nitrogeneous organic constituents in 2% yeast extract (basal medium) on production of cyclopiazonic acid (CA) by Penicillium verrucosum var. cyclopium was studied at room temperature. Maximum CA production was observed after 14 days in a medium containing 2% yeast extract +2.5% sucrose. Ammonium lactate had a negative effect on the production of CA by the test culture. Nitrogeneous organic constituents such as peptone and tryptone did not enhance the yield of CA in the medium. After an initial drop in the pH, a general increase in pH was observed as the incubation time increased. Curdled milk was also found to be a suitable medium for the production of CA by the mold culture.
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