Effect of Some New Aza – Uracil Derivatives in Treatment of Schistosoma mansoni Infection

Abstract

Praziquantel is now the drug of choice for treatment of schistosomiasis, its use in the control ofschistosomiasis at a population level faces some problems, and thus a search for new drugs withantischistosomal activity is urgently needed. In the present study we worked on newlysynthesized 1, 2, 4-triazine derivative compounds. The study was carried out on 190 femalemice for the assessment of the antischistosomal activity of 1,2,4-triazine compounds, withspecial reference to histopathological examination and some liver tissues biochemicalparameters. The results showed four compounds 3, 6, 7 and 10 caused suppressive effect on thedevelopment of granuloma reaction as compared with Schistosoma infected only. Compound 10had the highest effect in reducing worm burden lesser sever enzymatic dysfunction. Somecompounds caused a marked improvement in almost enzymatic activity particularly 5`-nucleotidase, G6P, Na-K ATPase and Mg-ATPase activities. ALT and AST activities decreasedthan the normal. Also, some compounds showed improvement in catalase and GST enzymeactivities indicating their antioxidant effect .Some compounds as 9 and 10 showed antischistosomalactivity; also compounds 3, 6 and 10 had anti-inflammatory activity.