Abstract
The influence of pentylenetetrazol (Cardiazol) on the Wulst EEG has been studied in 9 adult hens and in 15 adult pigeons under curarized conditions. Spikes with large amplitude (1–3 mV.) in the Wulst EEG were found to be elicited by intravenous injections of Cardiazol at dose of 50–100 mg./kg. body weight in the adult chicken as well as local applications of 10% Cardiazol upon the cerebral hemisphere of the adult chickens and pigeons. In the adult pigeon, definite spikes with large amplitude (1–3 mV.) were reliably induced by an intravenous dose of 100 mg./kg. Cardiazol. In addition, the present investigations have demonstrated that threshold spiking was electroencephalographically shown with the injection of 2 mg./kg. strychnine nitrate in the adult pigeon, and that it was about 2 times higher in adult pigeons than in adult hens. Furthermore, the present results indicate that spikes obtained by Cardiazol are essentially similar to those elicited by strychnine nitrate in the avian EEG.
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