Effect of Solanum nigrum Linn against Lambda CyhalothrinInduced Toxicity in Rats

Abstract

Introduction: Lambda-cyhalothrin is a type II pyrethroid insecticide and may cause liver damage. Solanum nigrum may act as hepatoprotective agent; therefore we aimed to study the effect of solanum nigrum (dried fruits or its ethanolic extract) against lambda cyhalothrin toxicity in rats. Materials and Methods: Thirty three male Sprague Dawlay rats were divided into 6 groups (G1: normal; G2 & 3: normal treated with ethanolic extract of the dried fruits, and dried fruits respectively; G4: normal rats intoxicated with Lambda cyhalothrin; G5 & 6: as G2 & 3 but intoxicated with lambda cyhalothrin. At the end of the experiment (6 weeks), the rats were sacrificed and blood was taken for the determination of AST, ALT, Alk Ph, LDH, Hb, Hct, MCH, MCHC and RBC count. Lactate dehydrogenase (LDH) was measured in serum and brain. Results and Discusion: A significant decrease in body weight, Hb and Hct level was observed in G4 (Lambda cyhalothrin intoxicated rats). The intoxicated groups (G 5 & 6) treated with ethanolic extract or dried fruits of Solanum nigrum showed an improvement of body weight, Hb and Hct where a significant increase compared to G4 but still significantly lower than G1 was observed trying to return to normal or near normal level. A significant increase in AST, ALT and Alk Ph level was observed in G4. Group 5 & 6 showed an improvement of AST, ALT and Alk Ph level where a significant decrease compared to G4, but still significantly higher than G1, was observed trying to return to normal or near normal. Conclusion: Our results demonstrate that S. nigrum fruits or alcoholic extract was able to reverse the pathological parameters and may be useful as an antioxidant and hepatoprotective agent.