Abstract
The promoting effect of sodium caprate (CAP) added to a progesterone mixed suppository was investigated in vitro and in vivo. The mixed suppository (S50), consisting of Witepsol W35 and ethylene-vinyl acetate copolymers (EVA40Y and EVA250); and a control suppository of Witepsol W35 (C50) were prepared by the fusion method. One or five percent of CAP was added to S50 and C50 containing 50 mg of progesterone. The release of progesterone from C50 was not influenced by the addition of CAP and there was no change in plasma level profile of progesterone after administration to the vagina of rabbits. On the other hand, S50 added with CAP showed rapid elevation of the plasma level of progesterone without any change in the sustained-release characteristics.
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