DOPPEROMETRIC PARAMETERS OF URINE BLOOD VESSELS WITH DIFFERENT SCHEMES OF SUPPORT OF LUTEIN PHASE

Abstract

The aim of the study was to determine the Doppler parameters of the blood flow of the uterus vessels in various schemes of support of the luteal phase (LF).Material and methods of research. Surveyed 60 women who were divided into 2 groups. The first consisted of 50 women (main group), who participated in the program of egg donation. The 2nd (control group) included 10 donors who were in the natural menstrual cycle. In the patients of the main group, on the day of follicular aspiration, support for the luteal phase (LF) began. On the 5th day, a Doppler study of the endometrium was performed. The control group included donors in the natural menstrual cycle, in which endometrial dopplerometry was performed on the 5th day after ovulation. Patients of the main group, according to the method of LF support, were divided into 5 subgroups (10 people each). The first subgroup included women who received Didrogesterone 10 mg orally 3 times a day, in the 2nd subgroup highly purified progesterone was used for subcutaneous administration, which was used 25 mg (1 ml) once a day and 90 mg of intravaginal progesterone in in the form of a gel, in the 3rd subgroup - micronized progesterone in capsules 200 mg 3 times a day per os, in the 4th subgroup an intravaginal gel containing 90 mg of progesterone was used, 2 times a day every day, in the fifth subgroup women received 1 ml 2.5% progesterone twice a day /im.Results. By the beginning of LF support in the main group of patients in the uterine, spiral, radial and arcuate arteries, according to Doppler, changes in blood flow characteristics in the spiral arteries are observed: the pulsation index and resistance index were statistically significantly higher than in the control group of women, while the systolic-diastolic ratio was significantly lower. In the radial arteries, the pulsation index was increased, and in the arcuate arteries, the pulsation index, the increased resistance index and the systolic-diastolic ratio were significantly reduced.Conclusion. After the treatment, hemodynamic improvement was observed in the uterus vessels according to the Doppler study. However, the most optimal is the support of LF with highly purified progesterone for subcutaneous administration at a dose of 25 mg and 90 mg of progesterone in the form of a vaginal gel.