Abstract
The sensitivity to sodium and potassium of the adenosinetriphosphatase activity of rat liver mitochondria at various stages of degradation was studied. In intact mitochondria no differences could be detected in sodium or potassium chloride media; in the presence of gramicidin and 2,4-dinitrophenol, the behavior of the reaction was independent of the cationic environment. However, when the mitochondrial structure was disrupted or altered by deoxycholate or sonication, a significant greater activity was encountered in the potassium-containing tubes. The soluble enzyme extracted from mitochondrial acetone powders showed also a higher activity in potassium medium. The response of the adenosinetriphosphatase system to sodium and potassium seems to depend on the structural conditions of the mitochondria.
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