Abstract
No study has so far evaluated the impact of coffee drinking on ocular wavefront aberration (OWA) measurements. This study presents novel findings regarding the OWA of the eye following coffee intake. We aimed to evaluate the acute changes in pupil size and OWA of the eye after single administration of coffee. A total of 30 otherwise healthy participants were included in this prospective study. All subjects drank a cup of coffee containing 57 mg caffeine. Measurements of pupil size, total coma (TC), total trefoil (TF), total spherical aberration (TSA), and total higher order aberration (HOA) were performed before and at 5 minutes, at 30 minutes, and at 4 hours after coffee drinking using a wavefront aberrometer device (Irx3, Imagine Eyes, Orsay, France). The mean age of the study population was 20.30 ± 2.74 years. Pupil size did not show a significant change during the measurements (p > 0.05). A significant increase was observed in TF and HOA measurements following coffee intake (p = 0.029 and p = 0.009, resp.). Single administration of coffee results in significant increase in TF and total HOAs in healthy subjects without any effect on pupil diameter. Ultrastructural changes in the cornea following coffee intake might be of relevance to the alterations in ocular aberrations in healthy subjects.
Highlights
Caffeine is a methylxanthine derivate alkaloid found in many food and various beverages such as coffee, tea, and colaflavoured drinks
The purpose of this study is to evaluate the acute effect of coffee on ocular wavefront aberration (OWA) along with pupil size measurements in healthy subjects
Until recently no study has evaluated the effect of coffee intake on OWA measurements of the eye in healthy subjects
Summary
Caffeine is a methylxanthine derivate alkaloid found in many food and various beverages such as coffee, tea, and colaflavoured drinks. Caffeine has been demonstrated to be associated with increased blood pressure, decreased heart rate, and reduced cerebral blood flow. The level of caffeine content was reported to be highest in coffee among the dietary products [1, 2]. Caffeine has been shown to be associated with changes in intraocular pressure (IOP), retinal and choroidal thickness, and pupil size [3,4,5,6]. It has been known that constriction of the pupil is related to parasympathetic outflow from the EdingerWestphal nucleus. Studies have shown cholinergic stimulation of the constrictor muscle and alpha-adrenergic stimulation of the dilator muscle [7, 8]
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