Abstract
The effect of silver nanoparticles with an average diameter of 4.3 ± 1.5 nm, synthesized by the borohydride method, on the fluorescence intensity of the fluoroquinolone derivative, levofloxacin, is studied. It is found that the addition of Y3+ ions to the system levofloxacin–silver nanoparticles increases the intensity of the antibiotic intrinsic fluorescence by 2.5 times. An increase in emission is possible as a result of the formation of a rigid structure of the fluorescent center, as well as the simultaneous action of the surface plasmon resonance of nanoparticles and an external emission source on the fluorophore. Carrying out a complexation reaction in the medium of sodium dodecyl sulfate micelles on the simultaneous presence of silver nanoparticles ensures a fourfold increase in the fluorescence signal because of the self-organization of supramolecular structures in the solution. Fluorimetric procedures for the determination of levofloxacin in natural water and a medicinal preparation are proposed. The linearity range of the calibration graph is 1.0 × 10–9–1.0 × 10–6 М. The limit of detection is 3.0 × 10–10 M (3σ).
Published Version
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