Effect of Silver Nanoparticle Administration on Productive Performance, Blood Parameters, Antioxidative Status, and Silver Residues in Growing Rabbits under Hot Climate.

Magdy Abdelsalam,Moataz Fathi,Mohamed Mostafa,Mohamed Shehab-El-Deen,Mohamed Abd El-Razik,Tarek Ebeid,Ibrahim Al-Homidan,Osama Abou-Emera,Sherif Abdel Ghani

doi:10.3390/ani9100845

Abstract

Simple SummarySilver nanoparticles (AgNPs) were used for their antibacterial effects, which increase productive performance and immune response in poultry and rabbits. On the other hand, residues of silver in meat and the internal organs of treated animals may be toxic for human beings. The current results of using two doses of injecting AgNPs revealed that body weight significantly improved in rabbits given a low dose of AgNPs compared with control animals. For consumers’ health concerns, it is of interest to note that the amount of accumulated silver in blood plasma and meat increased dramatically with an increasing dose.The influence of subcutaneous injections of silver nanoparticles (AgNPs) on rabbit performance, hematological and biochemical parameters of blood, antioxidant status, and the residues of silver in meat and blood in two breeds (New Zealand White (NZW) and Jabali) of rabbits growing under high ambient temperature was evaluated. A total of 90 six-week-old rabbits (45 NZW and 45 Jabali) were randomly distributed into three equal treatment groups (control, 0.5 mg, and 1.0 mg AgNPs/kg body weight). The treated rabbits were injected twice a week for four consecutive weeks. The results revealed that AgNPs administration had no significant effect on average daily gain (ADG), feed intake, and feed conversion ratio (FCR). The NZW breed surpassed the Jabali breed in growth performance traits, carcass weight, dressing percentage, and cuts of mid parts and hind cuts. Administration of AgNPs had a significant effect on hematocrit (HCT) and platelet (PLT) values. Rabbits injected with AgNPs at a dose of 0.5 mg showed a lower plasma concentration of total cholesterol and triglycerides than that of control rabbits. The NZW breed had significantly low platelet, total cholesterol, and triglyceride values. Rabbits injected with 0.5 mg/kg BW had the lowest total antioxidant capacity and highest malondialdehyde (MDA) and glutathione peroxidase. The Ag residues were higher in blood than those in meat in treated rabbits. The local breed (Jabali) had significantly lower residues than the imported one (NZW) either in meat or in blood. However, the amount of accumulated silver in blood plasma and meat increased with increasing dose.

Highlights

The concept of nanotechnology depends on reducing particle size to change the physical and chemical nature of an element
Administration of AgNPs had a significant effect on final BW (p < 0.02)
Administration of AgNPs had no significant effect on average daily gain (ADG), FI, and feed conversion ratio (FCR)

Summary

Introduction

The concept of nanotechnology depends on reducing particle size to change the physical and chemical nature of an element. The technology of nanoparticles is widely used in various applications of nutrition, therapy, and medication. Nanoparticles are greatly considered in livestock and poultry production because of chemical and physical properties. Silver nanoparticles (AgNPs) are defined as particles sized less than 100 nanometers. Several studies have suggested that feeding of nanoparticles improved the digestive efficiency, immunity, and performance in livestock and poultry. The use of silver nanoparticles as a powerful disinfection agent due to the fact of its antibacterial and antifungal characteristics has led to its recent application in the animal production sector [1,2,3]

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