Abstract
The objective of the work was to study the effect of high-dose ion implantation (HDII) of NiTi surface layers with Si Ti, or Zr, on the NiTi biocompatibility. The biocompatibility was judged from the intensity and peculiarities of proliferation of mesenchymal stem cells (MSCs) on the NiTi specimen surfaces treated by special mechanical, electrochemical, and HDII methods and differing in chemical composition, morphology, and roughness. It is shown that the ion-implanted NiTi specimens are nontoxic to rat MSCs. When cultivated with the test materials or on their surfaces, the MSCs retain the viability, adhesion, morphology, and capability for proliferationin vitro, as evidenced by cell counting in a Goryaev chamber, MTT test, flow cytometry, and light and fluorescence microscopy. The unimplanted NiTi specimens fail to stimulate MSC proliferation, and this allows the assumption of bioinertness of their surface layers. Conversely, the ion-implanted NiTi specimens reveal properties favorable for MSC proliferation on their surface.
Highlights
Today, the treatment of ischemic heart disease (IHD) is still one of the most urgent and foreground problems of the world and national healthcare
Alloys based on titanium nickelide, or NiTi-based alloys, match in full measure the above requirements demonstrating superelasticity or so-called shape memory effect—the capability for accumulation of high strain (4–6%) and its reversible return without fracture [3,4,5]
The objective of the work is to study the biocompatibility of NiTi specimens treated by special mechanical, electrochemical, and high-dose ion implantation (HDII) methods and their effect on the proliferation of mesenchymal stem cells and cytotoxicity
Summary
The treatment of ischemic heart disease (IHD) is still one of the most urgent and foreground problems of the world and national healthcare. Among modern methods of IHD correction is intracoronary stenting [1, 2]. The treatment of a human vascular system with stents— endoprostheses—for increasing the lumen of vessels and keeping them open requires application of materials with high strength and high elastoplastic characteristics. Particular attention should be given to the surface treatment of endoprostheses. The surface of endoprostheses must have minimum adhesion to preclude the risk of growth of plain muscular tissue in the lumen of an implant whilst being biologically compatible and tolerable to medicines with which the implant surface will contact
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