Effect of Short-Course Oral Ciprofloxacin on Isoflavone Pharmacokinetics following Soy Milk Ingestion in Healthy Postmenopausal Women.

Nathathai Temyingyong,Nutthiya Hanprasertpong,Nut Koonrungsesomboon,Supanimit Teekachunhatean,Mingkwan Na Takuathung

doi:10.1155/2019/7192326

Nathathai Temyingyong, Nutthiya Hanprasertpong + Show 3 more

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https://doi.org/10.1155/2019/7192326

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Abstract

Soy isoflavones have several potential benefits related to postmenopausal health. Isoflavone glycosides, found predominantly in nonfermented soy products, e.g., soy milk, require conversion by gut microbiota to their respective bioavailable aglycones prior to absorption into portal circulation. Use of short-course oral ciprofloxacin for the treatment of acute uncomplicated cystitis, the incidence of which is increasing among postmenopausal women, might adversely affect gut microbiota. The objective of this one-group pre-post treatment study was to determine the effect of short-course oral ciprofloxacin on isoflavone pharmacokinetics in healthy postmenopausal women. Eleven postmenopausal subjects were assigned to consume a single oral dose of 375 mL UHT soy milk (SOY phase). Blood samples were collected immediately before soy milk ingestion and at specific times for 32 hours after soy milk ingestion. Following a washout period of at least seven days, subjects were assigned to take 250 mg oral ciprofloxacin after breakfast and dinner for three days, followed by a single oral dose of 375 mL UHT soy milk the next day (CIPRO/SOY phase). Blood samples were collected at the same time points as in the SOY phase. Plasma samples were treated with β-glucuronidase/sulfatase and plasma concentrations of aglycones (genistein and daidzein) were determined using high-performance liquid chromatography. Cmax, AUC0-t, and AUC0-∞ of both aglycones and Tmax of genistein obtained from the CIPRO/SOY phase were significantly lower than those obtained from the SOY phase, while Tmax of daidzein and t1/2 of both aglycones in the two phases were not significantly different.

Highlights

Soy isoflavones, nonsteroidal polyphenolic compounds found in soybeans [1], are structurally similar to 17β-estradiol and have estrogen-like effects [2, 3]
This study aimed to evaluate the effect of short-course oral ciprofloxacin on the pharmacokinetics of soy isoflavones in healthy postmenopausal women
It is noteworthy that the second peaks of both aglycones obtained from the CIPRO/SOY phase were remarkably lower than those of the SOY phase, whereas the short-course oral ciprofloxacin given in the CIPRO/SOY phase caused a slight reduction in the first peak concentrations of both aglycones in comparison to those observed in the SOY phase

Summary

Introduction

Nonsteroidal polyphenolic compounds found in soybeans [1], are structurally similar to 17β-estradiol and have estrogen-like effects [2, 3]. Soy isoflavones occur in three aglycone structures (daidzein, genistein, and glycitein), which can enter into three βglycoside conjugates (daidzin, genistin, and glycitin), each with its corresponding acetyl- and malonyl-glycoside conjugates. As glycitein and its glycoside conjugates account for less than 5-10% of the total isoflavones in soy-based products, most studies have focused on daidzein and genistein and their respective glycoside conjugates [12]. Regular consumption of isoflavone-rich soy milk alleviates climacteric symptoms (both somatic and urogenital domain symptoms) in peri- and postmenopausal women [14] and Evidence-Based Complementary and Alternative Medicine helps prevent lumbar spine bone loss in postmenopausal women [15]

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