Abstract
Objective To investigate thee protective effect of shenfu injection on myocardium in patieents undergong open caridiac surgey with cardiopulmonary bypass(CPB).Methods Sixty patients scherluled for selective cardiac surgery were randomly divided into Shebnfu group and control group with 30 cases respectively.In Shenfu group,2ml/kg Shenfu injection was added into membrane oxygenator before CPB.Blood samples were collected to measure the concentration of serum CK,CK-MB,LDH before operation,30rain after cross-of ascending aorta and 10 min after release of cross-clamp.The levers of serum cTnI were measured 30 min after cross-clamp of ascending aorta and 10 min after release of cross-clamp.The morphologic studies were made with a light microscope and and electron microscope.A mitochondrical stereology analysis was done.Results There were no diffenences on the activities of serum CK,CK-MB,LDH between two groups.The level of cTnI increasese obviously after release of cross-clamp,but Level of cTnI in Shenfu group was much lower than that in control group(P＜0.05).The morphologic and ultrastructual measurements indicated milder damages occurred in Shenfu group.Conclusion Shenfu injection may redue myocardial ischemia/reperfusion injury in patients undergoing cardiopumonary bypass. Key words: Myocardial rperfusion injury; Cardiopulmonary bypass; Cardium; Shenfu injection
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