Abstract
Studies concerned with the oral absorption characteristics of dicloxacillin from various pharmaceutical formulations in beagle dogs suggest that the female of this species shows consistently higher and more prolonged blood serum levels of the antibiotic than the corresponding male. An investigation was initiated to determine the extent of this phenomenon with respect to sodium dicloxacillin monohydrate and other penicillins. The results of these studies suggest that the monobasic penicillin molecules show blood serum level variations after oral administration that are related to the sex of the animal, while a similar correlation does not appear to exist for the amphoteric penicillins. Determination of the biological half-life of the various penicillins in the male and female after intravenous administration indicates that no sexual differences occur with respect to the disappearance of active drug from the blood.
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