Effect of sage (Salvia officinalis) aqueous extract on mitotic index in albino male mice

Roqaya, M Al-Ezzy,Khulood Al-Samarrae,Ali H Ad'Haih

doi:10.24126/jobrc.2010.4.1.91

Abstract

This study aimed to evaluate the effect of aqueous extract of sage (Salvia officinalis) on bone marrow cells in albino male mice by using three doses ( 83.9, 167.8 or 251.7 mg/kg) and cytosar drug at dose of ( 1.54 mg/kg). The results showed that sage has the ability to increase the mitotic index in mice in comparing with the negative control and in mice treated with cytosar drug that caused reduction in mitotic index. The results of pre- and post-treatment with the ideal dose of aqueous extract of sage and cytosar drug showed the ability of sage to increase the mitotic index of bone marrow cells in mice in comparing with the negative controls.

Highlights

Herbs are plants or plant parts that are valued for their medicinal and savory qualities
The list of drugs that are of a herbal origin is increased, and the World Health Organization (WHO) has established that out of 119 plant-derived pharmaceutical medicines, about 74% are used in modern medicine in ways that correlate directly with their traditional uses as plant medicines by native peoples [2]
Many studies that determine the activity of immune system and the effect of different agents on it depend on the ability of lymphocytes to proliferate in lymphoid organs and/or depend on dividing cells of bone marrow because it is the source of all blood cells [8]

Summary

Introduction

Herbs are plants or plant parts that are valued for their medicinal and savory qualities. They contain and can produce a variety of chemical substances that have different biological effects, with a special reference to their medicinal importance. They are employed by herbalists of different cultures, anciently and recently, to remedy peoples of their sicknesses [1]. Sage has a very long history of effective medicinal uses and is an important domestic herbal remedy for disorders of the digestive system. Mitotic index assay is defined as the ratio of the numbers of cells in a population undergoing mitosis to the total numbers of cells [9]

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Conclusion