Abstract
This study deals with the cytogenetic effect of lactobacillus acidophilus concentrated filtrate on metaphase index of bone marrow cells in mice. Cyclophosphamide is a drug that is used primarily for treating several types of cancer. In order to work, cyclophosphamide first is converted by the liver into two chemicals, acrolein and phosphoramide. The results showed that lactobacillus acidophilus concentrated filtrate caused a significant increased in metaphase index in comparison with the negative control (distilled water) and positive controls (Cyclophosphamide) especially at high doses. The results of interaction study showed that pre- and post-treatment with lactobacillus acidophilus concentrated filtrate caused a significant increased in metaphase index of mice bone marrow cells
Highlights
Under domesticated conditions, stress factors cause deficiencies to occur which render the animal vulnerable to infection
In pre-treatment interaction, the Lactobacillus acidophilus concentrated filtrate was given for 6 days (250 mg/kg single dose/day), while cyclophosphomide was given in day 7, and animals were sacrificed in day 8 for laboratory assessments
In post-treatment interaction, the animals was given cyclophosphomide on day one, while the Lactobacillus acidophilus concentrated filtrate was given in day 2 till day 7, and animals were sacrificed in day 8 for laboratory assessments
Summary
Stress factors cause deficiencies to occur which render the animal vulnerable to infection Under these circumstances, supplementation with live microorganisms to repair the deficiencies in the composition of the gut micro flora can stimulate an immune response and restore the animals resistance to infection [1]. There are over sixty different drugs used in chemotherapy, most being specific to certain types of cancer, these drugs are often used in combination having different mechanisms of action and metabolic pathways. Some of these chemotherapeutics agents are Cyclophosphamide, Ifosfamide, Chlorambucil, Melphalan, Busulphan which act as Alkylating Agents [4]. This study was aimed to evaluate the ability of concentrated filtrate of L.acidophilus in reducing the genotoxic effects of treatment with Cyclophosphomide, and the influence of concentrated filtrate of L. acidophilus-cyclophosphomide on metaphase index of bone marrow
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