Effect of Saccharomyces cerevisiae supplemented with silver nanoparticles on Propionibacterium acnes in vitro

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Abstract Background: Acne is a chronic inflammatory disease of the pilo-sebaceous unit of the follicles in the skin that most commonly affects people throughout their adolescence or teenage years. Around 85% of youngsters globally are affected by this skin condition, according to research. Acne, in contrast, is not only a teenager’s problem; in many cases, it lasts far into adulthood. Objective: The aim of this study was to investigate how Saccharomyces cerevisiae supplemented with silver nanoparticles impacted Propionibacterium acnes in Mosul City. Materials and Methods: Specimens were obtained from 65 acne patients who attended Mosul’s private dermatological clinics with signs of inflamed and discharged pus. The specimens inoculate on blood agar, MacConkey agar, nutrient agar, Muller Hinton agar, and nutrient broth. Then, the effect of S. cerevisiae with silver nanoparticles on P. acnes was determied. Results: The results showed different inhibition with various concentrations of yeast extract against P. acnes in the medium, with the 50% concentration showing the highest inhibition diameter at a rate of 18 mm in the bacteria under study, while the inhibition diameter was at an average rate of 18 mm. For each bacterium, the highest rate of inhibition was at a concentration of 40% and a diameter of 15 mm, whereas the lowest rate of inhibition was at a concentration of 30% and a diameter of 12 mm. Conclusions: Silver nanoparticles, when coupled with S. cerevisiae, can be a very effective antibacterial against to P. acnes.