Abstract
Rubiscolin-6 (YPLDLF) is a δ selective opioid peptide isolated from the enzymatic digests of ribulose bisphosphate carboxylase/oxygenase (Rubisco) from spinach leaves. In a step-through type passive avoidance test in ddY mice, rubiscolin-6 enhanced memory consolidation at doses of 3 nmol/mouse after intracerebroventricular administration, and at 100 mg/kg after oral administration. These doses are smaller than the optimal doses for an analgesic effect. The memory enhancing effect of rubiscolin-6 was blocked by pretreatment with the δ antagonist naltrindole, suggesting the involvement of the δ opioid receptor.
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