Effect of rosuvastatin intensive treatment on APN, BNP of myocardial infarction after PCI

Abstract

Objective To explore the effect of rosuvastatin intensive treatment on APN,BNP of myocardial infarction patients after PCI.Methods Ninety-six patients with acute myocardial infarction undergoing PCI with heart failure,were randomly divided into the control group of 32 cases (general treatment),and the treatment group of 32 patients (rosuvastatin,10 mg/d) and intensive group of 32 examples (rosuvastatin,20 mg/d),then we recorded the occurrence of adverse events during hospitalization and outside the hospital.On the basis of the general treatment one week prior to the treatment group and the intensive group patients taking these drugs,the first day after surgery,four weeks and eight weeks of fasting,take APN,BNP concentrations in serum were detected by ELISA and zymography.Results ① The plasma APN levels of PCI postoperative day 1,four weeks and eight weeks were significantly higher than those before surgery (P ＜ 0.05).After four weeks and eight weeks,the plasma APN levels of intensive group were significantly increased compared to the treatment and control groups (P ＜ 0.05); ② One day after PCI,4 weeks and 8 weeks,the plasma BNP levels were significantly lower than preoperative (P ＜ 0.05).After four weeks and eight weeks,compared to the treatment and control groups,the plasma BNP levels of rosuvastatin intensive group were significantly lower (P ＜ 0.05).Conclusion Rosuvastatin intensive treatment can significantly increase the plasma APN level and reduce BNP level,thereby protecting the coronary vascular endothelial cells and reducing the occurrence of in-stent restenosis,better than the dose rosuvastatin therapy through. Key words: Rosuvastatin; Intensive treatment; PCI; APN; BNP