Effect of rosuvastatin and atorvastatin on endothelial function and serum inflammatory factors in patients with unstable angina pectoris

Abstract

Objective To investigate the effects of rosuvastatin and atorvastatin on endothelial function and serum inflammatory factors in patients with unstable angina pectoris. Methods Sixty-two patients with unstable angina pectoris from December 2014 to January 2016 were selected, and they were divided into two groups according to the order of admission, with 31 cases in each group. The study group was treated with rosuvastatin, and the control group was treated with atorvastatin. The brachial artery flow mediated diastolic function (FMD), granule membrane protein-140 (GMP140), serum inflammatory factors and blood lipid levels between the two groups before and after treatment were compared. Results There was no significant difference in the levels of FMD, GMP140, serum inflammatory factors or blood lipid between the two groups before treatment (P>0.05). After treatment, both groups of patients were significantly improved than before treatment, and GMP140, LDL-C and TC levels in the study group were significantly better than those in the control group, the differences were significant (P<0.05). Conclusions Rosuvastatin and atorvastatin can make platelet aggregation and inflammatory response in patients with unstable angina pectoris, improve the endothelial function and blood lipid levels, and the effect of rosuvastatin on platelet aggregation was significantly better than that of atorvastatin. Key words: Rosuvastatin; Atorvastatin; Unstable angina pectoris; Endothelial function; Serum inflammatory factors