Abstract

Objective To investigate the effect of root canal filling calcium hydroxide paste combined with root canal on serum levels of inflammatory factors in treatment of dental pulp diseases and periapical periodontitis. Methods Eighty-two patients with pulpitis and periapical periodontitis from February 2015 to January 2016 were divided into control group (n=41) and study group (n=41) according to different dosage regimen. Both groups were treated with root canal therapy, the control group was treated with zinc oxide iodoform clove oil cement, the study group was given calcium hydroxide paste. The clinical curative effects, pain during root canal therapy (IAE) was observed. Before and after treatment between the two groups, periodontal index [gingival index (GI), periodontal probing depth (PD), bleeding on probing index (BI), plaque index (PLI)] [white blood cells and inflammatory factors interleukin -4 (IL-4), IL-6, high sensitive C reactive protein (hs-CRP), tumor necrosis factor alpha (TNF-alpha)] level changes were compared. Results The total effective rate of the study group (95.12%) was higher than that of the control group (78.05%), and the incidence of Ⅲ IAE (7.32%) was lower than that of the control group (34.39%), and the difference was significant (P 0.05), after treatment, the each indexes in study group were better than those in the control group, the difference was significant (P<0.05). Conclusions Root canal filling calcium hydroxide paste combined with root canal can effectively improve the serum levels of inflammatory factors and periodontal status in the patients with pulpitis and periapical periodontitis, root canal therapy can relieve period pain, improve the therapeutic effect, has the value of popularization. Key words: Calcium hydroxide paste; Root canal filling; Root canal treatment; Pulp disease; Periapical periodontitis

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