Effect of rivaroxaban in the prevention of deep vein thrombosis after total hip replacement in elderly diabetic patients and its influence on plasma D-dimer level

Abstract

Objective To investigate the effect of rivaroxaban in the treatment of deep vein thrombosis (DVT) after total hip replacement (THR) in elderly patients with diabetes mellitus and its influence on plasma D-dimer level. Methods 25 elderly patients with diabetes undergoing elective hip replacement (group B) and 25 elderly patients without diabetes mellitus (group A) were enrolled in this study.The two groups were orally given rivaroxaban for 2 weeks after operation.The results of color Doppler diagnosis of DVT were compared between the two groups, and the content of D-dimer in plasma was detected. Results Before and after operation, the INR between the two groups had no statistically significant differences (P>0.05). The D-dimer levels of the two groups before operation were obviously lower than those postoperative 2 and 7 days (t=3.145, P 0.05), the value of postoperative 2 days was significantly higher than those postoperative 7 and 14 days (t=3.763, P<0.05), the value of postoperative 7 days was significantly higher than those postoperative 14 days (t=2.876, P<0.05). There was no DVT in the two groups of A and B, and no severe bleeding occurred in the two groups. Conclusion Rivaroxaban in the treatment of elderly diabetic patients with THR surgery, can effectively reduce the formation of lower extremity DVT.At the same time, through detection of plasma D-dimer content can accurately judge the occurrence of DVT, which has guiding significance for prevention and treatment of DVT. Key words: hip replacement; diabetes mellitus; Shaaban; deep vein thrombosis