Effect of risperidone treatment on serum activity of superoxide dismutase and levels of malondialdehyde and S100B in first-episode schizophrenic patients

Dachun Chen ,Kebing Yang ,Ying Nie ,Ning Wang ,Meihong Xiu ,Yanli Li ,Yunlong Tan

doi:10.3760/cma.j.issn.1006-7884.2010.01.006

Dachun Chen , Kebing Yang + Show 5 more

https://doi.org/10.3760/cma.j.issn.1006-7884.2010.01.006

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Publication Date: Feb 5, 2010

Affiliation: Beijing HuiLongGuan Hospital

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Objective To explore the role of antioxidant enzymes and free radicals in the pathogensis of schizophrenia and effects of risperidone treatment.Methods Ninety first-episode schizophrenia inpatients according to the Dignostic and Statistical Manual of Mental Disorder Fouth Edition,were treated only with risperidone, observed for 12 weeks, and the clinical effects estimated with the Positive and Negative Syndrome Scale (PANSS).The biological markers including total anti-oxidant activity (TAC), total superoxide dismutase (T-SOD), cupro-zinc superoxide dismutase (Cu-ZnSOD), manganecesuperoxide dismutase (Mn-SOD), malondialdehyde (MDA) and S100B, were measured both in patients and controls (87 subjects).Results Activity of T-SOD and Cu-ZnSOD, S100B were significant increased in patients compare to controls [(732±126)×102U/Lvs.(672±115)×102 U/L;(578±175)×102 U/Lvs.(440±148)×102 U/L;(180±181) ng/Lvs.(101±115)ng/L;t=3.2, 5.6, 2.2;v=169,169, 60; P< 0.05].Mn-SOD activity was marked lower in patients compared to controls [(153±145)×102U/Lvs.(232±161)×102 U/L,t=-3.3,v =169, P<0.05].TAC activity was higher posttreatment compare to baseline [(150 ± 54)×102 U/L vs.( 174 ± 59)×102 U/L; t = - 2.6,v= 66,P<0.05].Mn-SOD activity in pre-treatment set up the regression equation with the improvement of PANSS total score(R =0.62 ,R2 = 0.38, F = 7.89, P = 0.02).TAC activity in pre-treatment set up the regression equation with the improvement of positive symptoms ( R = 0.71, R2 = 0.50,F=12.9,P = 0.00).Mn-SOD activity in pre-treatment and the changes in TAC between post-treatment and pre-treatment set up regression equation with the improvement negative symptoms( R =0.76, R2 = 0.58, F = 8.24, P = 0.00).Conclusion The free radicals and antioxidant enzymes may be involved in the pathology of schizophrenia, and risperidone treatment may improve antioxidant activity of first-episode schizophrenic patients. Key words: Schizophrenia; Free radicals; Superoxide dismutase; Malondialdehyde

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