Effect of Rhizophora sp mangrove leaf extract on mice blood glucose levels

Abstract

Diabetes mellitus is a disease that occurs due to increased blood glucose levels (hyperglycemia) due to disorders of the pancreas. Mangrove leaves are known as herbal plants that can reduce blood glucose levels because it contains flavonoid compounds that can repair damaged pancreatic β cells and stimulate pancreatic β cells to produce the hormone insulin. This study aimed to determine the effect of Rhizophora leaf extract administration in reducing blood glucose levels of mice. This research was an experimental laboratory with the approach the post-test only control group design. This test used 5 groups, consisting of negative control group, positive control group (Glibenclamide 5 mg/kg BW), KP1 (extract 250 mg/kg BW), KP2 (extract 500 mg/kg BW), KP3 (extract 700 mg/kg BW). Measurement of fasting blood glucose levels using glucometer. The results showed that the administration of Rhizophora leaf extract in the KP1, KP2, and KP3 treatment groups was able to reduce blood glucose levels compared to before being treated, although the decrease was not yet up to normal limits. The conclusion was that the Rhizophora leaf extract was able to reduce fasting blood glucose levels with the highest percentage reduction in KP2 at a dose of 500 mg/kg BW by 29%.