Abstract
Previously, we reported that the bioflavonoid resveratrol (RES), inhibits proliferation of rat theca-interstitial cells. This study evaluated the mechanisms of actions of RES on rat theca-interstitial cell proliferation and steroidogenesis. Since actions of RES may be due to inhibition of the mevalonate pathway, we investigated whether effects of RES were related to a decrease of isoprenylation substrates: farnesyl-pyrophosphate (FPP) and geranylgeranyl-pyrophosphate (GGPP).
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