Abstract
The objective of this study was to investigate the antibacterial effect of resveratrol against putative periodontal pathogens during the progression of experimental periodontitis in rats. Periodontitis was induced in rats in one of the first molars chosen to receive a ligature. Animals were assigned to one of two groups: daily administration of the placebo solution (control group, n = 12) or 10 mg/Kg of resveratrol (RESV group, n = 12). The therapies were administered systemically for 30 days, for 19 days before periodontitis induction and then for another 11 days. Then, the presence and concentrations of Porphyromonas gingivalis, Tannerella forsythia and Aggregatibacter actinomycetemcomitans in the cotton ligatures collected from the first molars were evaluated using real-time PCR. Inter-group comparisons of the microbiological outcomes revealed that no differences were detected for P. gingivalis, T. forsythia and A. actinomycetemcomitans levels (p > 0.05). Continuous use of resveratrol did not promote additional benefits in microbiological outcomes during experimental periodontitis in rats.
Highlights
Periodontitis is a major chronic inflammatory disease that is the most prevalent form of bone pathology in humans with up to 15% of the adult population affected by severe periodontitis at some point in their lives.[1]
Key periodontopathic bacteria, such as Porphyromonas gingivalis (Pg), Tannerella forsythia (Tf) and Aggregatibacter actinomycetemcomitans (Aa), are related to the beginning of periodontal disease and may prolong imbalance in the microbiota and the host response in periodontal tissues, which encourages the development of periodontitis.[2,4,5]
For the microbiological outcomes observed in this study, the inter-group comparisons revealed that there was no difference between groups for Aa, Pg or Tf levels (p > 0.05)
Summary
Periodontitis is a major chronic inflammatory disease that is the most prevalent form of bone pathology in humans with up to 15% of the adult population affected by severe periodontitis at some point in their lives.[1] This disease is characterized by an infection that leads to the occurrence of the destruction of the supporting tissue and induces a local production of immune-inflammatory mediators in response to periodontal pathogens and their products.[2] the nature of host immune-inflammatory responses to microbiota may motivate the pathology that is observed, the existence of one or more microorganisms that are considered to be a periodontal pathogen in sufficient numbers is needed to establish periodontitis.[3] Key periodontopathic bacteria, such as Porphyromonas gingivalis (Pg), Tannerella forsythia (Tf) and Aggregatibacter actinomycetemcomitans (Aa), are related to the beginning of periodontal disease and may prolong imbalance in the microbiota and the host response in periodontal tissues, which encourages the development of periodontitis.[2,4,5] there is a consensus that the response of the host against bacterial challenge is essential
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