Abstract

Syntheses of two regioisomeric series of atropisomeric amino alcohols and a comparative study on their application in the enantio­selective addition of diethylzinc to benzaldehyde are reported. Systematic modification of the electronic and steric properties of the functional groups resulted in highly efficient catalyst ligands in both series. Quantum-chemical calculations agreed well with the experimental results of this first systematic comparative study on regioisomeric ­atropisomeric ligands.

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