Abstract
Present study investigated the effects of red wine polyphenolic compounds (Provinols™) on blood pressure (BP) and vascular function in normotensive Wistar-Kyoto rats (WKY) exposed to chronic stress due to crowding. Adult male WKY were divided into four groups: control (480 cm2/rat), Provinols™-treated (20 mg/kg/day, 480 cm2/rat), crowded (200 cm2/rat) and crowded treated with Provinols™ (20 mg/kg/day, 200 cm2/rat) for 8 weeks. BP was determined using tail-cuff method. Endothelium-dependent relaxation to acetylcholine (ACh) was determined in the rings of isolated femoral and small mesenteric arteries. No differences in BP were observed among the groups at the end of experiment, however, reduced BP was observed in Provinols™-treated rats after 3 weeks of treatment. Vasorelaxation of the femoral and small mesenteric arteries was significantly improved in stressed and Provinols™-treated rats. Combination of both factors had no effect on vasorelaxation in the femoral artery vs. control, however it accentuated vasorelaxation in the small mesenteric arteries vs. stress. In conclusion, increased endothelium-dependent relaxation in both types of arteries in crowded rats may represent adaptation resulting in unaltered values of BP during chronic stress. Provinols™ improved vasorelaxation during stress in the small mesenteric arteries, and maintained normal relaxation in the femoral artery.
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