Abstract
<p><strong>Introduction: </strong>The consumption of high fat and sugar can increase the risk of metabolic syndrome. <em>Hylocereus polyrhizus</em> is known to be able to lower total cholesterol levels in the blood. This study aims to determine the effect of <em>Hylocereus polyrhizus</em> extract on total cholesterol levels in Wistar rats with the metabolic syndrome model.</p><p><strong>Methods: </strong>This study used laboratory experimental research using a pretest and posttest with a control group design. The sample consisted of 30 Wistar rats according to the inclusion criteria which were divided into 5 groups: K1 (positive control), K2 (negative control), K3, K4, and K5 (treatment group). The treatment group was given <em>Hylocereus polyrhizus</em> extract with doses of 60, 120, and 180 mg/200grW. Total cholesterol levels were measured on the 8th, 36th, and 64th day. The data were analyzed using the parameterized One-way ANOVA test followed by Tukey's HSD posthoc test, paired T-test, and Pearson's correlation test.</p><p><strong>Results: </strong>The average total cholesterol after being given by <em>Hylocereus polyrhizus</em> extract in K3 (137 ± 2.82 mg/dL), K4 (109 ± 2.31 mg/dL), and K5 (100 ± 2.38 mg/dL) was lower than the negative control group. Data analysis showed significant differences (p&lt;0.05) in total cholesterol levels before and after treatment in all groups. The Pearson correlation test explained that the variation dosage of <em>Hylocereus polyrhizus</em> extract had a very strong correlation with a positive correlation with total cholesterol levels.</p><p><strong>Conclusion: </strong>Induction of <em>Hylocereus polyrhizus</em> extract at doses of 60, 120, and 180 mg/200grW was able to significantly reduce total cholesterol levels.</p>
Published Version
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