Abstract
BackgroundChronic obstructive pulmonary disease (COPD) is a common and frequently occurring respiratory disease. At present, western medicine treatment of COPD mainly focuses on symptomatic treatment. Using Chinese medicines or integrated Chinese and Western medicines to treat stable COPD has significant efficacy. In this study, we aimed to observe the effect of Radix Stemonae concentrated decoction on the lung tissue pathology and inflammatory mediators in COPD rats and explore its possible mechanism.MethodsSD rats were randomized into blank group, COPD model group and Radix Stemonae group, 10 cases in each group. Rats were fed for 112 days. Before the rats were sacrificed, lung function of the animals was tested. The right lower lung was fixed for morphologic observation. The inflammatory mediators in serum were determined using enzyme-linked immuno sorbent assay.ResultsBody weight of animals in the model group was significantly decreased compared with blank group (P < 0.05). After gavage therapy with Radix Stemonae, body weight was significantly increased (P < 0.05). Compared with the blank group, pulmonary functions of rats in the model group were significantly abnormal (P < 0.05), while in Radix Stemonae group, these indicators turned much better than model group (P < 0.05). As for pathological changes in lungs, airway inflammation in the model group was aggravated. In the Radix Stemonae group, inflammation and emphysema were much milder. The concentrations of TNF-α, IL-8 and LTB4 in both model group and Radix Stemonae group were increased significantly (P < 0.05). But the levels in Radix Stemonae group were decreased significantly than model group (P < 0.05).ConclusionRadix Stemonae concentrated decoction may mitigate and improve airway rebuilding in the lungs of COPD rats by inhibiting the release of inflammatory mediators.
Highlights
Chronic obstructive pulmonary disease (COPD) is a common and frequently occurring respiratory disease
The results showed that Radix Stemonae lung-nourishing fried paste could mitigate the clinical symptoms of COPD patients, improve their quality of life [19]
Radix Stemonae concentrated decoction may mitigate and improve airway rebuilding in the lungs of COPD rats by inhibiting the release of inflammatory mediators
Summary
Chronic obstructive pulmonary disease (COPD) is a common and frequently occurring respiratory disease, which is characterized by persistent airflow limitation [1]. It is often complicated with exacerbations and. Stemonae Radix is a traditional Chinese medicine (TCM) used as an antitussive and insecticidal remedy, which is derived from Stemona tuberosa Lour, S. japonica and and S. sessilifolia [11]. It has been widely used for the treatment of respiratory diseases in China for thousands of years. The pharmacokinetics study of multiple components absorbed in rat plasma after oral administration of Stemonae radix showed that croomine and tuberostemonine would be potential bioactive components for the treatment of chronic or acute cough in rat model [17, 18]
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