Effect of Quercetin on Haematobiochemical and Histological Changes in the Liver of Polychlorined Biphenyls-Induced Adult Male Wistar Rats.

Senthamilselvan Bavithra,Gunasekaran Krishnamoorthy,Firdous Ahmad Bhat,Kandaswamy Selvakumar,Jagadeesan Arunakaran,Sekaran Suganya

doi:10.1155/2013/960125

Senthamilselvan Bavithra, Gunasekaran Krishnamoorthy + Show 4 more

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https://doi.org/10.1155/2013/960125

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Abstract

Polychlorinated biphenyls exposure damages the rat liver cells. Hematological parameters such as hemoglobin, packed cell volume, red-blood cells, white-blood cells, neutrophils, platelet counts, and RBC indices were significantly decreased. Polymorphs, eosinophil counts, and erythrocyte sedimentation rate were significantly increased. Serum liver enzymes such as aspartate transaminase, alanine transaminase, alkaline phosphatase, and gamma-glutamyl transferase were increased by PCBs treatment. Serum lipid profiles such as cholesterol, triglycerides, low-density lipoproteins and very-low-density lipoproteins were increased in PCBs-treated rats. High-density lipoprotein, total protein, albumin, globulin levels, and albumin/globulin ratio were also decreased after PCB exposure. Then levels of sodium, potassium, chloride, and bicarbonate were also altered. Serum glucose levels were increased along with total bilirubin after PCBs exposure. Simultaneous quercetin supplementation significantly protected the PCBs-induced changes of hematobiochemical parameters. Thus, quercetin shows a protective role against PCBs-induced alterations in the hematological and biochemical parameters.

Highlights

Polychlorinated biphenyls (PCBs) are industrial chemicals used in plasticizers, surface coatings, inks, adhesives, ame retardants, pesticide extenders, paints, and microencapsulation of dyes for carbonless duplicating paper
Polymorphs, eosinophils counts, and erythrocyte sedimentation rate were signi cantly increased by PCB treatment, but the values of Hb, packed cell volume (PCV), RBC, BC, neutorphils, and platelet rates were signi cantly increased with simultaneous administration of quercetin along with PCB
The mean corpuscular volume (MCV) value was signi cantly decreased in PCB-treated rats, mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC) values did not alter in PCB- or quercetin-treated rats

Summary

Introduction

Polychlorinated biphenyls (PCBs) are industrial chemicals used in plasticizers, surface coatings, inks, adhesives, ame retardants, pesticide extenders, paints, and microencapsulation of dyes for carbonless duplicating paper. Further environmental contamination may occur from the disposal of old electrical equipment containing PCBs. eir characteristic low solubility, contribute to its ability to bioconcentrate which leads to bioaccumulation. E production of PCBs peaked in the 1970s and has steadily declined therea er as many countries throughout the world have banned their use or limited their production. These compounds remain in use today in our environment and represent a potential human health hazard [2]. PCBs are environmental toxicants associated with numerous adverse health effects, through widespread bioaccumulation in the biosphere and bioconcentration in the food chain [3]. Oxidative impairment occurs when generation of ROS overrides the ability of the antioxidant system to neutralize ROS subsequently leading to both an increase in oxidative processes and a decrease in antioxidant defenses

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