Abstract
Slices of rabbit or rat brain cortex were preincubated with [ 3H]noradrenaline, and slices of rabbit caudate nucleus or rat striatum with [ 3H]dopamine. The slices were then superfused and stimulated electrically. In rat cortex slices, PGE 2 (0.01–1 μmol/l) markedly reduced the stimulation-evoked overflow of tritium. PGF 2α (1 μmol/l) caused a slight decrease only after the formation of endogenous prostaglandins had been blocked by indomethacin. PGD 2 (1 μmol/l) had no effect. In slices of rabbit cortex and caudate nucleus as well as in rat striatal slices, none of the prostaglandins (1 μmol/l) caused any change, irrespective of whether the production of endogenous prostaglandins was intact or blocked. The results show that, of three major prostaglandins that occur in the brain, only PGE 2 is a potent presynaptic inhibitor of noradrenaline release in the rat. The catecholamine neurones of rabbit brain, and the dopamine neurones of rat striatum, are resistant to these prostaglandins.
Published Version
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