Abstract
Effect of Prophylactic Ondansetron on Norepinephrine Consumption for Spinal Anaesthesia induced Hypotension in Caesarean Section: A Prospective Study
Highlights
Spinal anaesthesia is a referred technique for elective caesarean section due to its simplicity, ability to provide adequate surgical anaesthesia, higher maternal satisfaction, ease of administration, faster onset of action, and safety [1]
Systolic & diastolic blood pressures were comparable at all time intervals between both groups
The incidence of maternal hypotension after spinal anaesthesia during caesarean delivery is as high as 50-80% [2] which can be detrimental to both mother and foetus
Summary
Spinal anaesthesia is a referred technique for elective caesarean section due to its simplicity, ability to provide adequate surgical anaesthesia, higher maternal satisfaction, ease of administration, faster onset of action, and safety [1]. Many techniques & various vasopressors have been tried and studied to manage hypotension following spinal anaesthesia, but no single method was found to be adequate or superior. Many studies suggested that injection norepinephrine managed hypotension effectively with more stable hemodynamic profile than other vasopressor [3,5]. 5-HT is an important factor inducing Bezold-Jarisch Reflex (BJR) via 5-HT3 receptor located in intracardiac vagal nerve endings and cardiac wall. Activation of Bezold-Jarisch reflex (BJR) by decreased venous return to right heart stimulates 5-hydroxytryptamine type 3 (5HT3) receptors located in cardiac wall, leading to vasodilation, bradycardia and hypotension. The aim of the present study was to assess the effect of prophylactic intravenous ondansetron on norepinephrine consumption used for treatment of SAIH following spinal anaesthesia for caesarean delivery
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