Effect of probiotics on glucose metabolism in patients with type 2 diabetes mellitus: A meta-analysis of randomized controlled trials

Abstract

ObjectiveOur aim was to investigate the effects of probiotics on glucose metabolism in patients with type 2 diabetes mellitus using a meta-analysis of randomized, controlled trials. Materials and methodsOnline databases Embase, Web of Science, and PubMed were searched until August 2014 to identify eligible articles. Finally, 7 trials were included. ResultsProbiotic consumption significantly changed fasting plasma glucose (FPG) by −15.92mg/dL (95% confidence interval [CI], −29.75 to −2.09) and glycosylated hemoglobin (HbA1c) by −0.54% (95% CI, −0.82 to −0.25) compared with control groups. Subgroup analysis was conducted to trials with non-yogurts control. Meta-analysis of trials with multiple species of probiotics found a significant reduction in FPG (weighted mean difference [WMD]: −35.41mg/dL, 95% CI: −51.98 to −18.89). The duration of intervention for ≥8 weeks resulted in a significant reduction in FPG (WMD: −20.34mg/dL, 95% CI: −35.92 to −4.76). Subgroup analysis of trials with species of probiotics did not result in a significant meta-analysis effect. Furthermore, the duration of intervention <8 weeks did not result in a significant reduction in FPG. The results also showed that probiotic therapy significantly decreased homeostasis model assessment of insulin resistance (HOMA-IR) and insulin concentration (WMD: −1.08, 95% CI: −1.88 to −0.28; and WMD: −1.35mIU/L, 95% CI: −2.38 to −0.31, respectively). ConclusionsThe present meta-analysis suggests that consuming probiotics may improve glucose metabolism by a modest degree, with a potentially greater effect when the duration of intervention is ≥8 weeks, or multiple species of probiotics are consumed.