Abstract
Extraction socket healing is a critical process in dental care that determines the success of subsequent dental treatments, such as implant placement. Platelet-rich fibrin (PRF) has emerged as a promising biomaterial for enhancing wound healing in various medical and dental applications. This abstract aims to provide a comprehensive overview of the effect of PRF on extraction socket healing, with a particular focus on the sample size of studies conducted in this area. PRF is an autologous blood-derived product rich in growth factors, cytokines, and platelets, which play key roles in tissue repair and regeneration. When applied to extraction sockets, PRF promotes accelerated wound healing by stimulating angiogenesis, enhancing cell proliferation, and modulating the inflammatory response. These biological effects contribute to improved soft tissue healing and osseous regeneration. A thorough review of the literature reveals that several studies have investigated the effect of PRF on extraction socket healing, with varying sample sizes. Sample sizes ranged from small-scale studies with fewer than 20 participants to larger-scale investigations involving over 100 subjects. The inclusion of sufficient sample size is crucial for obtaining statistically significant results and ensuring the generalizability of findings.
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