Abstract
Effects of Prednison therapy on serum levels of T4, T3, rT3, TBC, basal TSH and TSH response to TRH in 10 children (7 with nephrotic syndrome, 3 with trombocytopenia) were studied. It has been found out that corticotherapy (Prednison 1--2 mg/kg/24 h; 2--4 weeks) causes a significant decrease of total T3 concentration together with a considerable rise of reverse T3 and lower T3-binding capacity. Basal TSH level was increased about twice; TSH response to TRH between both groups (without and with Prednison therapy) did not differ significantly. The observations suggest the presence of hypothyroidism during chronic corticotherapy in children.
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