Abstract
Summary In this study, the effects of group antibodies on red blood cell volume was investigated by means of a method based on optical density. Corresponding antibodies caused an increase in volume whereas non-corresponding antibodies had a decreasing effect. Prednisolone and cocaine could not completely prevent those changes in volume by stabilizing red blood cell membrane, but they significantly minimized the increase. As a result there seemed to be two mechanisms in the changes in red blood cell volume induced by corresponding antibodies. One of them was prevented by prednisolone and cocaine possibly by stabilizing the membrane.
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