Abstract
Hypochromic blood from patients with thalassaemia or iron‐deficiency anaemia has been incubated at 37° C in vitro for up to 72 h. Prelytic changes in red cell volume, Na+ and K+ have been studied. It was found that the abnormal changes in red cell volume that occurred during the incubation period could be correlated with the low MCHC values. These abnormal volume changes were attributable to abnormalities in red cell Na+ and K+ flux. Evidence is presented that in these red cells with low MCHC values there is an abnormally high net efflux of K+ and an abnormally low influx of Na+ when the cells are allowed to become metabolically depleted during incubation.
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