Abstract
PurposeThe goal of our research was to investigate the possibility of using drug loaded intra‐ocular lenses (IOLs) as an alternative to topical antibiotic usually prescribed after cataract surgery.MethodsAlthough widely used in drug release studies due to its simplicity in comparing systems, static conditions are far from reproducing biological conditions. A microfluidic cell mimetizing chamber's aqueous humor hydrodynamic is a much closer approach. With a volume of 250 µL, the cell is fed with a continuous flow of saline solution at a physiological similar rate.ResultsResults showed that 30 days preconditioned IOLs were able to maintain a MXF concentration above the minimum inhibitory concentrations for Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus pneumoniae for 20 days.ConclusionsFurther investigation in using moxifloxacin loaded IOls as effective to prevent post cataract surgery endophthalmitis is encouraged.
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