Effect of Praziquantel, Allicin, and Curcumin on The Histology of Liver, Spleen, and Kidney of Schistosoma mansoni Infected Mice.

Abstract

Background: Human schistosomiasis was considered a tropical disease causing histological deformation in different organs.Aim of the Work: To focus on the possible therapeutic efficiency of praziquantel (PZQ), allicin (AL), and curcumin (CU) in healing the histopathological disorders in Schistosoma mansoni infected mice.Material and Methods: Ninety mice were divided into two main groups; uninfected and infected groups. From the 7th week, post-infection, the groups begin their treatment with the different regimens. PZQ (300 mg/kg) groups were given the drug orally for two successive days. The groups of AL (40 mL/kg) or CU (40 mg/kg) were given by intraperitoneal injection for two weeks. The histological changes of the liver, spleen, and kidney were recorded to determine the effect of each treatment.Results: AL and CU were able to ameliorate these histopathological lesions resulted from infection competitively with PZQ. In the liver, the highest reduction rate in granuloma number was recorded in the infected mice treated with CU while the highest reduction rate in granuloma diameter was recorded in the PZQ-treated group. The infected groups treated with PZQ or AL showed mild alternation in splenic structures. The most ameliorative healing effect was noticed in the infected mice treated with CU as there were no lesions recorded in spleen tissue. The all tested elements caused lesions in both the non-infected and the infected animals.Conclusion: This promising research suggests the potential efficacy of AL, and CU in ameliorating the histopathological effects of schistosomiasis, in a competitive manner with PZQ. We recommended for further investigations to use AL and CU as complementary drugs with PZQ and to study the effect these drugs on different organs' functions based on the biochemical tests.