Abstract
DEVIATIONS from the normal electrocardiogram have been reported in schizophrenic patients in the course of insulin-shock therapy.1Thiamine deficiency2; hypoglycemia3; anoxia, with decreased blood flow through the coronary arteries,4and epinephrine release5have been implicated in these changes. Other investigators have demonstrated the occurrence of hypopotassemia in diabetic acidosis and in other clinical disorders and have described characteristic cardiovascular and electrocardiographic changes associated with decreased serum-potassium concentration.6Messinger4and Hadorn1bobserved that the most frequent electrocardiographic abnormalities associated with hypoglycemia was a flattening or inversion of the T wave and sinus arrhythmia; other findings were a pathological Q wave in lead III, changes in R and S voltage, slight widening of the QRS complex, and appearance of U waves or auricular and ventricular extrasystoles. Bellet and his co-workers,6hfound similar changes in pattern associated with hypopotassemia and classified these as follows:
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