Abstract
DEATHS from acute radiation injury with doses of 500–1,000 r. are assumed to be a consequence of a typical bone-marrow syndrome characterized by septicaemia, haemorrhagic diathesis and anaemia. Attempts have been made to alleviate these conditions. Antibiotics have been used successfully to prevent septicaemia1,2, but the excellent results from the injection of fresh haemopoietic tissue3,4 are complicated by the fact that the irradiated animals recover their ability to react against foreign proteins5. This may result in a homograft reaction in the recipient6,7. Agents have therefore been sought to induce recovery in the bone-marrow of irradiated animals8–10. Stimulation of erythropoiesis in sub-lethally irradiated rats by anaemic plasma was presumed to be caused by its erythropoeitin content11, but no systematic investigation has been made to test the value of erythropoietin(s) in radiation injury. This investigation was undertaken to examine the effect of post-treatment with erythropoietin(s) on the survival and erythropoietic recovery of lethally irradiated mice.
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