Abstract
Objective To study the protective effect of pyrrolidine dithiocarbamate (PDTC) on acute irradiated mice. Methods The 6-8 weeks old male ICR mice were randomly divided into five groups: irradiation alone group (IR), positive control group (amifostine WR-2721 250 mg/kg) and PDTC of 30, 60 and 90 mg/kg dose groups. Each group had 10 mice and the drug was given at 0.5 h before whole body irradiation. At 30 d post-irradiation of 7.5 Gy 137Cs γ-rays, the mice survival were observed. At 8 d post-irradiation of 5.0 Gy 137Cs γ-rays, the peripheral blood, hematopoietic system and organ indexes were observed to evaluate the radiation protective effect of PDTC. Results PDTC increased the 30-day survival rates and 60 mg/kg dose had the most obvious effect by increase the survival to 60%(6/10). The survivals of irradiation alone group and the amifostine positive control group was 10%(1/10) and 70%(7/10), respectively. Compared with the irradiation alone group, 60 mg/kg PDTC group had the significant difference in spleen index, WBC, HGB, PLT, bone marrow nucleated cells and colony forming unit of spleen(t=2.354, 4.793, 2.342, 6.542, 2.649, 3.982, P<0.05). Conclusions PDTC is effective in radiation protection with an optimum dose of 60 mg/kg. Key words: Pyrrolidine dithiocarbamate; γ-rays; ICR mice; Radiation injury
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