Abstract
Objective To investigate the effect of positive end expiratory pressure (PEEP) on intra-abdominal pressure (IAP) in critical patients with different pulmonary diseases. Methods 72 critical patients undergoing mechanical ventilation (MV) were enrolled in this study in Intensive Care Unit from January 2012 to December 2016. According to their lung lesions, the patients was divided into three groups: chronic obstructive pulmonary disease (COPD) group, acute respiratory distress syndrome (ARDS) group, and normal group, 24 cases in each group. IAP, lung compliance (CL), total compliance (CT), and thoracic compliance (CTH) were obtained with a horizontal position under different PEEP conditions of 0, 3 ,6, 9,12, and 15 cmH2O (1 cmH2O = 0.098 kPa). The relationship between IAP and PEEP, CL, CT, and CTH were analyzed. Results The effect of PEEP on IAP in critical patients with different pulmonary diseases: ARDS group < normal group < COPD group (P<0.05). Lung compliance in each group: ARDS group < normal group < COPD group (P<0.05). Positive correlation was found between IAP and PEEP (r=0.92, P<0.01). There were closed correlation between IAP and CL, CT, CTH (r=0.83, 0.64, -0.56; P<0.05). Conclusion There are major differences in the effect of PEEP on IAP among the patients with different pulmonary diseases. The effect is related to the lung compliance. Key words: Intra-abdominal pressure; Positive end expiratory pressure; Lung compliance
Published Version
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