Abstract
Lung supportive devices are widely used for respiratory ventilation and therapy to help providing breathing support for patients with various lung diseases including Obstructive Sleep Apnea. These devices deliver continuous air to the patient through a nasal or a facial mask. However, the use of these devices normally results in dryness in the upper airways. Various methods have been developed to improve the continuous positive pressure features using pressure oscillations, which can reduce the patient requirements such as reduction in the titration pressure and humidification requirements. Thus, the objective of this research is to investigate the differences between continuous positive pressure and positive pressure oscillation on the upper airway humidification. Human nasal (RPMI 2650) and bronchial (Calu-3) epithelial cells grown in air-liquid interface on permeable supports are used as a respiratory model. Trans-epithelial electrical resistance is measured before and after each experiment to evaluate the cell layer integrity and permeability.
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