Effect of Pomegranate and Mixed Fruit Juice in Radiation Exposed Female Webster White Mice (Mus musculus) Linn.

Abstract

Too much exposure to x-ray radiation causes side effects that contribute to behavioral change. The researchers conducted a study on pomegranate, grapes, and apples which are fruits high in polyphenols and anti-oxidants. The study is about the effect of pomegranate and mixed fruit juice supplementation for two weeks on female Webster white mice (Mus musculus) Linn prior to irradiation and evaluation. Sixteen mice were divided into four groups (control, supplement with radiation exposure, no supplement with exposure group, and supplement with no exposure group) and all groups were exposed to a specified water maze test after irradiation of radiation groups and eighteen hours after the first water maze test. A histopathological study was then conducted to assess the hepatoprotective effect of the supplement. The results of the water maze test indicate a constant performance in the mice based on the objectives with a faint evidence of memory and spatial learning enhancement. Histopathologies found in the mice were fewer in pomegranate groups which show alleviation of liver condition as compared to no supplementation groups. Researchers recommend assessing the amount and administration of the supplement, controlling the environment and pre-screening to ensure no external factors affect mice behavior and health.  Keywords - Radiologic  Technology,  x-ray  radiation, pomegranate, grapes,   apples, antioxidants, polyphenols, memory,  spatial  learning,    hepatoprotective  ei¬€ect,  histopathology, experimental design, Philippines. Â