Abstract
Early osseointegration is important to achieve initial stability after implant placement. We have previously reported that atmospheric-pressure plasma treatment confers superhydrophilicity to titanium. Herein, we examined the effects of titanium implant material, which was conferred superhydrophilicity by atmospheric-pressure plasma treatment, on the surrounding tissue in rat femur. Control and experimental groups included untreated screws and those irradiated with atmospheric-pressure plasma using piezobrush, respectively. The femurs of 8-week-old male Sprague-Dawley rats were used for in vivo experiments. Various data prepared from the Micro-CT analysis showed results showing that more new bone was formed in the test group than in the control group. Similar results were shown in histological analysis. Thus, titanium screw, treated with atmospheric-pressure plasma, could induce high hard tissue differentiation even at the in vivo level. This method may be useful to achieve initial stability after implant placement.
Highlights
Komasa et al reported that titanium and nanostructured zirconia/alumina composite (NANOZR) implant materials modified by ultraviolet (UV), atmospheric-pressure plasma, and alkali treatments can promote the early formation of hard tissue in the tissue surrounding the implant [16,17,18,19,20,21,22,23,24,25]
It was investigated how the atmospheric pressure plasma treatment on the titanium surface would affect the surface of the material
We showed that the concentrated alkali treatment of titanium forms a nanometer-scale mechanical structure on the titanium surface, which is helpful for advancing the initial adhesion ability of rat bone marrow cells (RBMCs) and the ability to induce hard tissue differentiation [16,17,18]
Summary
Many researchers have shown that surface modification of implant materials influences bone formation and maintenance at the interface, and plays a major role in osseointegration [1,2,3,4,5]. Changes in the surface roughness of the material surface have been reported to contribute to increased bone marrow cell adhesion and differentiation. It has been reported that when there is an increase in the surface roughness of the titanium surface, which is one of the main materials for implant materials, the initial adhesion, proliferation, differentiation of bone-related cells, and protein adsorption increases [12,13,14,15]. Other commonly used surface-treatment methods include acid etching, sandblasting, anodization, physical vapor deposition, calcium phosphate coating, and hydroxyapatite coating [1,2,3,4,5,6,7,8,9,10,11]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
