Effect of plasma fibrinogen level on leukoaraiosis in patients with subcortical vascular dementia

Abstract

Objective To investigate the effect of levels of fibrinogen,plasma homocysteine,and blood lipids on the degree of leukoaraiosis in patients with subcortical vascular dementia (SVD).Methods Blood levels of fibrinogen,homocysteine,high-density lipoprotein,low-density lipoprotein,apolipoprotein A,apolipoprotein B,triglyceride,and total cholesterol were measured in 37 hospitalized or clinic patients with SVD.Head was detected by magnetic resonance.According to Scheltens' s apporach,deep white matter hyperintense signals (DWMH) and periventricular hyperintensity (PVH) were determined semiquantitatively.All the collected biochemical indicators and risk factors were compared with the semiquantitative scores of DWMH and PVH.The clinical datas were analyzed by Pearson correlation analysis and single linear regression analysis.Results Pearson correlation analysis showed only plasma Fib level was positively related to the degree of PVH in SVD (P=0.034),and this relation didn' t exist between leukoaraiosis (DWMH and PVH) and other biochemical indicators (P＞0.05).Single linear regression analysis revealed leukoaraiosis (DWMH and PVH) was not related with hypertension,smoking,stroke,diabetes,and hyperlipoidemia (P＞0.05).Conclusions Plasma level of Fib is positively related with the degree of periventricular hyperintensity in subcortical vascular dementia. Key words: Subcortical vascular dementia; Leukoaraiosis; Fibrinogen