Effect of Pinellia Ageratum Decoction on Cisplatin-induced Vomiting and Its Mechanism

Abstract

The present study was to investigate the effect of Pinellia Ageratum Decoction on vomiting induced by cisplatin in rats and its mechanism. The experiment was divided into blank control group, cisplatin model group, ondansetron hydrochloride group, Major Pinellia Decoction group and Pinellia Ageratum Decoction group. The vomiting model was established by intraperitoneal injection of cisplatin in rats. At the end of the experiment, the amount of kaolin consumption, food intake, gastric residual rate, gastric binding mucus volume and small intestinal propulsion rate were observed and measured. Serum 5-hydroxytryptamine (5-HT) and dopamine levels were detected by ELISA. The results demonstrated that compared with the blank group, the amount of kaolin consumption in the model group increased significantly and the food intake decreased significantly. Compared with the model group, the amount of kaolin consumption in pinellia ageratum decoction group decreased significantly, the food intake increased significantly, the amount of gastric-binding mucus increased significantly, the rate of small intestinal propulsion increased significantly, and the differences were significant (P < 0.05), level of 5-HT decreased slightly, there was no significant difference, the level of dopamine decreased significantly, and the difference was significant (P < 0.05) pinellia ageratum decoction group has a therapeutic effect on cisplatin-induced vomiting in rats, and its mechanism may be related to its reduction of dopamine levels in rats.