Abstract
Untrained healthy male volunteers were studied to observe the effects of muscular exercise (bicycle ergometer, 150 W for 15 min and 30 min) upon the levels of carbonic anhydrase B(CA-B) and C(CA-C) isozymes and 2,3-diphosphoglycerate (2,3-DPG) in erythrocyte cells. Significant decreases in the levels of both CA-B and total carbonic anhydrase activity were observed after 15 min as well as after 30 min of exercise whereas the level of CA-C did not vary substantially. The level of 2,3-DPG increased after 30 min of exercise. A negative correlation was found between the levels of CA-B and 2,3-DPG after 30 min of exercise (r = -0.635) while no significant correlation was found after 15 min of exercise. The blood lactate-pyruvate ratio increased above the pre-exercise values after 15 min of ex-ecercise but not after 30 min of exercise. After 30 min of exercise, the increase in lactate concentration and the change of 2,3-DPG correlated well (r = 0.668). These observations suggest that the steady-state level of CA-B is affected by physical exercise more readily than that of CA-C and that the changes in the levels of these isozymes and 2,3-DPG in erythrocyte cells are requisite for adaptation to prolonged exercise.
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